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DTSTART;TZID=Europe/Stockholm:20220627T133000
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UID:submissions.pasc-conference.org_PASC22_sess121_msa181@linklings.com
SUMMARY:Toward Multiscale Modelling of Blood Flow using CFD-DEM Techniques
DESCRIPTION:Minisymposium\n\nToward Multiscale Modelling of Blood Flow usi
 ng CFD-DEM Techniques\n\nSaeedipour, Porcaro, Pirker\n\nModelling blood fl
 ow with the description of biophysics at the cellular level is essential f
 or many bio-microfluidics applications. Despite the maturity of the state-
 of-the-art cell-resolved simulation techniques for microscopic scales, the
 ir applicability as a modelling tool for real-life engineering application
 s with large-scale computational domains may still be limited to large com
 putational cost. Multiscale methods could be potential remedy for this sho
 rtcoming by combining different modelling approaches across the scales. In
  this study, we present our strategy for multiscaling in the context of fi
 nite volume-based resolved and unresolved CFD-DEM techniques. Herein, the 
 blood is assumed as a suspension of several interacting deformable and sti
 ff particles in liquid plasma resembling blood components i.e. RBC, WBC, a
 nd platelets. Using an immersed boundary technique, we adopt our previousl
 y developed reduced-order model for deformable particles as well as standa
 rd models for rigid spherical and non-spherical particles to simulate bloo
 d in microchannels. The simulation results show reasonable agreements with
  literature in producing characteristics of blood flow such as RBC migrati
 on and CFL formation. This will serve as the basis for unresolved CFD-DEM 
 simulations for a larger number of cells, where proper closure models will
  be developed for under-resolved physics such as cell deformation, aggrega
 tion, and rupture.\n\nDomain: Engineering, Life Sciences
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