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DTSTART;TZID=Europe/Stockholm:20220627T140000
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UID:submissions.pasc-conference.org_PASC22_sess121_msa193@linklings.com
SUMMARY:Multiphysics and Multiscale Modeling of Microthrombosis in COVID-1
 9
DESCRIPTION:Minisymposium\n\nMultiphysics and Multiscale Modeling of Micro
 thrombosis in COVID-19\n\nLi, Deng, Li, Gallastegi, Mantzoros...\n\nEmergi
 ng clinical evidence suggests that thrombosis in the microvasculature of p
 atients with Coronavirus disease 2019 (COVID-19) plays an essential role i
 n dictating the disease progression. We employ a novel multiphysics and mu
 ltiscale computational framework to investigate the underlying mechanism o
 f the pathological formation of microthrombi and circulating cell clusters
  in COVID-19. We quantify the contributions of many prothrombotic factors 
 reported in the literature, such as stasis, the derangement in blood coagu
 lation factor levels and activities, inflammatory responses of endothelial
  cells and leukocytes to the microthrombus formation in COVID-19, through 
 which we identify the potential targets that should be further evaluated, 
 and prioritized in the anti-thrombotic treatment of patients with COVID-19
 .\n\nDomain: Engineering, Life Sciences
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