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DTSTART;TZID=Europe/Stockholm:20220627T173000
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UID:submissions.pasc-conference.org_PASC22_sess134_msa201@linklings.com
SUMMARY:Characterisation of Cellular Properties and Dynamics in Microfluid
 ics
DESCRIPTION:Minisymposium\n\nCharacterisation of Cellular Properties and D
 ynamics in Microfluidics\n\nZhang, Chien, Gompper, Fedosov\n\nSorting cell
 s based on their intrinsic properties is highly desirable, since changes i
 n cell deformability are often associated with various stress conditions a
 nd diseases. Deterministic lateral displacement (DLD) devices offer high p
 recision for rigid spherical particles, while their success in sorting def
 ormable particles remains limited due to the complexity of cell traversal 
 in such devices. We employ mesoscopic hydrodynamics simulations to better 
 understand flow properties of red blood cells (RBCs) traversing through di
 fferent DLD devices. In particular, we demonstrate prominent advantages of
  sharp-edged obstacles for probing deformability properties of RBCs. Furth
 ermore, we illustrate how single cell dynamics governs its motion through 
 DLD devices, which can serve as a possible sorting strategy. Interestingly
 , good sensitivity to changes in intrinsic properties of RBCs requires fin
 e-tuning of flow conditions, including flow strength and device geometry. 
 We expect that similar mechanisms should be applicable for the development
  of novel microfluidic devices that target intrinsic properties of many ot
 her cells.\n\nDomain: Engineering, Life Sciences
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