BEGIN:VCALENDAR
VERSION:2.0
PRODID:Linklings LLC
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
X-LIC-LOCATION:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20220812T074334Z
LOCATION:Rio Room
DTSTART;TZID=Europe/Stockholm:20220628T120000
DTEND;TZID=Europe/Stockholm:20220628T123000
UID:submissions.pasc-conference.org_PASC22_sess144_msa206@linklings.com
SUMMARY:Cellular Flow Mechanics in Healthy and Diabetic Complex Vessels
DESCRIPTION:Minisymposium\n\nCellular Flow Mechanics in Healthy and Diabet
 ic Complex Vessels\n\nZavodszky, Spieker, Hoekstra\n\nBlood is a dense sus
 pension of deformable capsules and its rheology arises from a variety of h
 ydrodynamic interactions on the level of its constituents. Modelling blood
  flow cases with complex geometries, high shear rate arterial conditions, 
 or larger domain sizes remain challenging. HemoCell was developed to addre
 ss these challenges using an improved cellular mechanical model, novel bou
 ndary conditions, and highly-optimised algorithms that were recently shown
  to scale well even above 250,000 CPU cores. In this work we present the r
 esults of the most recent applications including: the effect of the increa
 sed rigidity of diabetic red blood cells on platelet margination, the incr
 ease in wall shear stress in real retinal microaneurysms as cells are tran
 sported, and the effect of curved and stenosed geometries on high shear ra
 te platelet aggregation. The simulation setups for all cases correspond to
  in vitro and in vivo obtained geometries and flow conditions where the en
 vironment and the technological limitations only allow indirect observatio
 n of certain parameters. The simulations are employed primarily to reprodu
 ce the experimental conditions to provide further detailed insight into th
 e mechanisms. The additional information complements the measurements to f
 urther our understanding on the respective pathologies.\n\nDomain: Enginee
 ring, Life Sciences
END:VEVENT
END:VCALENDAR