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DTSTART:19700308T020000
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DTSTAMP:20220812T074334Z
LOCATION:Rio Room
DTSTART;TZID=Europe/Stockholm:20220628T113000
DTEND;TZID=Europe/Stockholm:20220628T120000
UID:submissions.pasc-conference.org_PASC22_sess144_msa219@linklings.com
SUMMARY:Red Blood Cell Dynamics in Complex Vascular Networks with HemeLB: 
 Implications in Development and Disease
DESCRIPTION:Minisymposium\n\nRed Blood Cell Dynamics in Complex Vascular N
 etworks with HemeLB: Implications in Development and Disease\n\nBernabeu, 
 Krüger\n\nIn this talk, I will review recent progress on the application o
 f High Performance Computing cellular flow simulations (with the HemeLB fl
 ow solver) to characterise red blood cell (RBC) dynamics in complex vascul
 ar networks. First, I will demonstrate an intriguing association between r
 educed RBC flow and vascular remodelling during vascular development. Seco
 nd, I will present two recently published studies relating vascular phenot
 ypes encountered in the tumour microenvironment with anomalous RBC transpo
 rt and potential tumour tissue hypoxia, a mechanism previously unreported.
  Finally, I will outline future research directions related to predicting 
 vascular network function from its structure and how this can become a too
 l for biomedical investigation and eventually clinical translation.\n\nDom
 ain: Engineering, Life Sciences
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