BEGIN:VCALENDAR
VERSION:2.0
PRODID:Linklings LLC
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
X-LIC-LOCATION:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20220812T074335Z
LOCATION:Rio Room
DTSTART;TZID=Europe/Stockholm:20220628T180000
DTEND;TZID=Europe/Stockholm:20220628T183000
UID:submissions.pasc-conference.org_PASC22_sess158_msa111@linklings.com
SUMMARY:Taking Cell-Based Models for Epithelial Dynamics to the Third Dime
 nsion
DESCRIPTION:Minisymposium\n\nTaking Cell-Based Models for Epithelial Dynam
 ics to the Third Dimension\n\nVetter, Runser, Iber\n\nUntil recently, comp
 uter simulations of tissue mechanics and epithelial morphogenesis were lar
 gely restricted to reduced spatial dimensions or simplified geometries and
  inter-cellular interactions due to the high geometric complexity and daun
 ting numerical costs associated with the complex shape and arrangement of 
 cells. The most prominent example is the popular two-dimensional vertex mo
 del, which represents double cell membrane interfaces as straight edges. R
 ecent advances in imaging technologies, algorithms, and computer hardware 
 now enable more realistic models of epithelial dynamics with subcellular f
 eatures. In this talk I present our recent developments on three-dimension
 al tissue models with high spatial and temporal resolution, exploiting con
 cepts from high-performance computing such as GPU parallelization and spat
 ial partitioning. With these techniques, 3D mechanical simulations of tiss
 ues with thousands of detailed cells with complicated, non-convex shapes a
 re becoming accessible. Taking the leap from 2D to 3D models is essential 
 to address open problems in morphogenesis and disease, such as lumen forma
 tion, vesicle formation, and the maintenance and loss of epithelial integr
 ity.\n\nDomain: Computer Science and Applied Mathematics, Life Sciences, P
 hysics
END:VEVENT
END:VCALENDAR